Further demonstration of induction of ovulation with a hybrid human chorionic gonadotropin compound (AB1ER-CR-2XY)
| Autor: | Raphael Jewelewicz, Barbara Shortle, Eugenia Rosemberg |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Menotropins medicine.drug_class media_common.quotation_subject AB1ER-CR-2XY medicine.medical_treatment Biology Chorionic Gonadotropin Human chorionic gonadotropin Ovulation Induction Internal medicine Follicular phase medicine Humans Ovulation reproductive and urinary physiology media_common Chemotherapy Obstetrics and Gynecology Endocrinology Reproductive Medicine HMG-CoA reductase biology.protein Female Ovulation induction Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and Sterility. 46:865-869 |
| ISSN: | 0015-0282 |
| Popis: | Further demonstration of the ability of the hybrid human chorionic gonadotropin (hCG) compound, AB1ER-CR-2XY, to induce ovulation is presented. Nineteen patients previously treated with human menopausal gonadotropin (hMG) and commercial hCG were selected for the study. The patients received 37 courses of treatment with dosages of hMG ranging from 1200 IU (16 ampules) to 8400 IU (112 ampules), followed by the administration of 5000 or 10,000 IU of the hybrid hCG. Of the total number of courses given, 75.5% were ovulatory; serum progesterone levels at midluteal phase of the cycle were within normal range, and the cycle length was about 12 days. Seven patients became pregnant, three with twins, one with triplets, and three with aborted single fetuses. Before the hybrid hCG was administered the serum estrogen levels were less than 1200 pg/ml in 12 cycles (32.4%), and the estrogen levels ranged from 1400 to 7400 pg/ml in 25 (67.6%). However, in spite of high estrogen levels, clinical hyperstimulation, which occurred in 22.4% of previous treatments with conventional hMG-commercial hCG, did not develop when the hybrid hCG was administered, an effect which could be attributed to its short circulatory half-life. Studies are in progress to confirm whether the hybrid hCG may provide a better margin of safety than commercial hCG for ovulation induction in patients pretreated with hMG. |
| Databáze: | OpenAIRE |
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