Diterpene Biosynthesis in Actinomycetes: Studies on Cattleyene Synthase and Phomopsene Synthase
| Autor: | Jeroen S. Dickschat, Simon T. Steiner, Jan Rinkel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diterpene biosynthesis
Oxidative phosphorylation 010402 general chemistry medicine.disease_cause 01 natural sciences Catalysis Nocardia Terpene chemistry.chemical_compound Polyisoprenyl Phosphates medicine Fragmentation (cell biology) chemistry.chemical_classification Biological Products Streptomyces cattleya Alkyl and Aryl Transferases ATP synthase biology 010405 organic chemistry Stereoisomerism General Chemistry 0104 chemical sciences Enzyme Biochemistry chemistry Cyclization biology.protein Diterpene Diterpenes Oxidation-Reduction |
| Zdroj: | Angewandte Chemie (International ed. in English). 58(27) |
| ISSN: | 1521-3773 |
| Popis: | Three diterpene synthases from actinomycetes have been studied. The first enzyme from Streptomyces cattleya produced the novel compound cattleyene. The other two enzymes from Nocardia testacea and Nocardia rhamnosiphila were identified as phomopsene synthases. The cyclisation mechanism of cattleyene synthase and the EIMS fragmentation mechanism of its product were extensively studied by incubation experiments with isotopically labelled precursors. Oxidative transformations expanded the chemical space of these unique diterpenes. |
| Databáze: | OpenAIRE |
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