Prevalence of Subclinical Hypothyroidism in Patients with End-Stage Renal Disease and the Role of Serum Albumin: A Cross-Sectional Study from South India
| Autor: | Viraj Bhise, Ghanshyam Palamaner Subash Shantha, Anita A Kumar, Kamesh Sivagnanam, Kuyilan Karai Subramanian, Rohit C Khanna |
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| Rok vydání: | 2011 |
| Předmět: |
Original Paper
endocrine system medicine.medical_specialty Creatinine endocrine system diseases biology Cross-sectional study business.industry Urology Serum albumin Albumin Logistic regression Gastroenterology End stage renal disease chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Thyroid function Cardiology and Cardiovascular Medicine business Subclinical infection |
| Zdroj: | Cardiorenal Medicine. 1:255-260 |
| ISSN: | 1664-5502 1664-3828 |
| Popis: | Background/Aim: Subclinical hypothyroidism (SCH) and end-stage renal disease (ESRD) are independent risk factors for cardiovascular mortality. We aimed to study the prevalence of SCH in ESRD patients and assessed its associated risk factors. Methods: This cross-sectional study was conducted at 2 tertiary-care centers in Chennai, India, over a 3-year period. The study group comprised 137 patients with ESRD on thrice weekly regular maintenance hemodialysis. Free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were measured using an electrochemiluminescence immunoassay. SCH was defined as TSH ranging between 4.5 and 10 mIU/l with normal FT4 (0.93–1.7 ng/dl). Patients with overt hypothyroidism, SCH and overt hyperthyroidism, those on medications affecting thyroid function and pregnant women were excluded from the study. Results: Of 137 ESRD patients (mean age: 43 ± 13.38 years), 107 were males (78.1%), 45 diabetics (32.8%), 127 hypertensives (92.7%), and 38 smokers (27.7%). Prevalence of SCH was 24.8%. In unadjusted (OR: 3.37, 95% CI: 1.91–5.21) and adjusted (for age, gender, HbA1C, and albumin/creatinine ratio; OR: 3.11, 95% CI: 2.15–4.98) logistic regression analysis, serum albumin was significantly associated with SCH. Further, multiple linear regression identified that for every 1 g/dl drop in serum albumin TSH increased by 4.61 mIU/l (95% CI: 2.75–5.92). Conclusion: We observed a high prevalence of SCH in our ESRD patients. Also, serum albumin was significantly associated with SCH in our study. |
| Databáze: | OpenAIRE |
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