Nucleus of the solitary tract chemical stimulation induces extracellular norepinephrine release in the lateral and basolateral amygdala
| Autor: | María Isabel Miranda, Nadia Edith García-Medina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Biophysics Stimulation Amygdala Potassium Chloride lcsh:RC321-571 Rats Sprague-Dawley Norepinephrine Internal medicine Nucleus of solitary tract medicine Solitary Nucleus Animals lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neurons Chemistry General Neuroscience Neurotransmitter release Solitary tract respiratory system Rats medicine.anatomical_structure Endocrinology nervous system Noradrenaline Catecholaminergic cell groups Neurology (clinical) Neuroscience Nucleus Basolateral amygdala medicine.drug |
| Zdroj: | Brain Stimulation, Vol 6, Iss 2, Pp 198-201 (2013) |
| Popis: | The NTS catecholaminergic neurons, activated by a variety of afferent stimuli, are ideally situated to coordinate afferent signaling to multiple brain regions. In particular, there is evidence that systemic epinephrine injections induce a significant increase of norepinephrine (NE) in the amygdala during enhanced memory, which can be disrupted by NTS chemical blockade or interruption of vagal afferents. The present experiment was conducted to obtain information about the levels of NE release induced by activation of the whole NTS, which projects to the lateral and basolateral amygdala. Therefore, we compared NE levels before and after general stimulation of the NTS and the amygdala in anesthetized rats, without any behavioral or vagal stimulation, to find out the degree of noradrenergic activation modulated by the NTS through all its projections to the lateral and basolateral amygdala, as well as the degree of noradrenergic activation which may occur locally in the amygdala through rapid and general activation of this structure. |
| Databáze: | OpenAIRE |
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