Dietary astaxanthin enhances immune response in dogs
| Autor: | Boon P. Chew, Gregory A. Reinhart, Jean Soon Park, Michael G. Hayek, Bridget D Mathison, Stefan Patrick Massimino |
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| Rok vydání: | 2011 |
| Předmět: |
Cytotoxicity
Immunologic medicine.medical_specialty Immunology Population Inflammation Lymphocyte proliferation Xanthophylls Lymphocyte Activation Immunoglobulin G chemistry.chemical_compound Dogs Immune system Adjuvants Immunologic Astaxanthin Internal medicine Leukocytes medicine Animals Hypersensitivity Delayed education education.field_of_study General Veterinary biology Acute-phase protein Diet Killer Cells Natural C-Reactive Protein Endocrinology Immunoglobulin M chemistry biology.protein Female medicine.symptom Acute-Phase Proteins DNA Damage |
| Zdroj: | Veterinary Immunology and Immunopathology. 140:199-206 |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/j.vetimm.2010.12.004 |
| Popis: | No information is available on the possible role of astaxanthin on immune response in domestic canine. Female Beagle dogs (9-10 mo old; 8.2 ± 0.2 kg body weight) were fed 0, 10, 20 or 40 mg astaxanthin daily and blood sampled on wk 0, 6, 12, and 16 for assessing the following: lymphoproliferation, leukocyte subpopulations, natural killer (NK) cell cytotoxicity, and concentrations of blood astaxanthin, IgG, IgM and acute phase proteins. Delayed-type hypersensitivity (DTH) response was assessed on wk 0, 12 and 16. Plasma astaxanthin increased dose-dependently and reached maximum concentrations on wk 6. Dietary astaxanthin enhanced DTH response to vaccine, concanavalin A-induced lymphocyte proliferation (with the 20mg dose at wk 12) and NK cell cytotoxic activity. In addition, dietary astaxanthin increased concentrations of IgG and IgM, and B cell population. Plasma concentrations of C reactive protein were lower in astaxanthin-fed dogs. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune response and reduced DNA damage and inflammation in dogs. |
| Databáze: | OpenAIRE |
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