Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice
| Autor: | Rita C. Carvalho, D.C. Gomes, Vanessa C. Abílio, Regina H. Silva, Daniela F. Fukushiro, Roberto Frussa-Filho, Isabel Ribeiro, Cibele Cristina Chinen, Raquel Levin, N.P. Araujo, R. de A. Ribeiro, J.L.S. Cunha |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Clinical Biochemistry Toxicology Biochemistry Behavioral sensitization Locomotor activity Mice Behavioral Neuroscience Internal medicine medicine Animals Amphetamine Saline Biological Psychiatry Sensitization Pharmacology Analysis of Variance Behavior Animal Ethanol Locomotor sensitization Endocrinology medicine.anatomical_structure Homogeneous Anesthesia Home cage Female Psychology medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 84:142-147 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2006.04.019 |
| Popis: | The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0 mg/kg for 13 days — Experiment 1) or saline or ETOH (1.8 g/kg for 21 days — Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages — HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages — HET-HC). Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. In both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior. |
| Databáze: | OpenAIRE |
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