Delayed generation of thrombin in clotting blood of atopic patients with hayfever and asthma

Autor:	M. Schmitz-Schumann, Andrzej Szczeklik, Chr. Virchow, M. Krzanowski
Rok vydání:	1991
Předmět:	Hemostasis Allergy Aspirin Bleeding Time medicine.diagnostic_test business.industry Immunology Thrombin Rhinitis Allergic Seasonal Heparin medicine.disease Asthma Atopy Bleeding time medicine Humans Immunology and Allergy Platelet business Fibrinopeptide A medicine.drug
Zdroj:	Clinical Experimental Allergy. 21:411-415
ISSN:	1365-2222 0954-7894
Popis:	There have been several reports on alterations of platelet function and raised plasma heparin levels in symptom-free atopic subjects. Either of these can affect formation of thrombin in vivo. In 25 symptom-free atopic patients and 32 healthy volunteers we studied the generation of thrombin in blood emerging from a standardized skin microvasculature injury, which also served to determine bleeding time. Generation of thrombin was delayed in atopics. They produced significantly less thrombin (P less than 0.01) during the early and central phase of haemostasis. The amount of thrombin generated was inversely correlated to bleeding time, which in atopics was on average 50 sec longer than in controls (P = 0.055). Two hours after ingestion of 500 mg aspirin, this difference increased up to 150 sec, although the individual responses varied markedly (P = 0.08), while the generation of thrombin became strongly depressed in both groups. The possible clinical relevance of the delayed formation of thrombin in atopy awaits further studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d524e99768963eb98dd708b57d4f120f https://doi.org/10.1111/j.1365-2222.1991.tb01680.x Zobrazit plný text záznamu Plný text ve formátu PDF