Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics
| Autor: | Dorien Groenendaal, Meindert Danhof, Jan Freijer, Elizabeth C. M. de Lange, Glynis Nicholls, Dennis de Mik, Andrea Rosier, Andrew Ayrton, Anne Hersey |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Intrinsic activity Butorphanol Pharmaceutical Science Quantitative Structure-Activity Relationship Pharmacology Permeability Fentanyl Cell Line Sufentanil Diffusion Dogs Pharmacokinetics In vivo medicine Animals Tissue Distribution ATP Binding Cassette Transporter Subfamily B Member 1 Alfentanil Rats Wistar Models Statistical Chemistry Electroencephalography Rats Analgesics Opioid Morphine Algorithms medicine.drug |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 34(2-3) |
| ISSN: | 0928-0987 |
| Popis: | The objective of this investigation is to characterize the role of complex biophase distribution kinetics in the pharmacokinetic-pharmacodynamic correlation of a wide range of opioids. Following intravenous infusion of morphine, alfentanil, fentanyl, sufentanil, butorphanol and nalbuphine the time course of the EEG effect was determined in conjunction with blood concentrations. Different biophase distribution models were tested for their ability to describe hysteresis between blood concentration and effect. In addition, membrane transport characteristics of the opioids were investigated in vitro, using MDCK:MDR1 cells and in silico with QSAR analysis. For morphine, hysteresis was best described by an extended-catenary biophase distribution model with different values for k1e and keo of 0.038+/-0.003 and 0.043+/-0.003 min(-1), respectively. For the other opioids hysteresis was best described by a one-compartment biophase distribution model with identical values for k1e and keo. Between the different opioids, the values of k1e ranged from 0.04 to 0.47 min(-1). The correlation between concentration and EEG effect was successfully described by the sigmoidal Emax pharmacodynamic model. Between opioids significant differences in potency (EC50 range 1.2-451 ng/ml) and intrinsic activity (alpha range 18-109 microV) were observed. A statistically significant correlation was observed between the values of the in vivo k1e and the apparent passive permeability as determined in vitro in MDCK:MDR1 monolayers. It can be concluded that unlike other opioids, only morphine displays complex biophase distribution kinetics, which can be explained by its relatively low passive permeability and the interaction with active transporters at the blood-brain barrier. |
| Databáze: | OpenAIRE |
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