Elderly Living Donor Liver Transplant Recipients Over 60 Years Old at a Japanese Single Center
| Autor: | Takashi Ito, Shuji Nobori, Hidetaka Ushigome, Tsukasa Nakamura, Toshimasa Nakao, K. Koshino, T. Suzuki, S. Harada, Norio Yoshimura |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Subarachnoid hemorrhage medicine.medical_treatment 030230 surgery Liver transplantation Single Center Cohort Studies End Stage Liver Disease 03 medical and health sciences 0302 clinical medicine Japan Recurrence medicine Living Donors Humans Stage (cooking) Survival rate Aged Transplantation business.industry Patient Selection Graft Survival Age Factors Hepatitis C Middle Aged medicine.disease Surgery Liver Transplantation Survival Rate Treatment Outcome 030211 gastroenterology & hepatology Female business Cohort study |
| Zdroj: | Transplantation proceedings. 48(4) |
| ISSN: | 1873-2623 |
| Popis: | Background Among living donor liver transplant (LDLT) recipients, the number of elderly individuals has been increasing because of longer survival due to the improvement of treatment for hepatic diseases such as hepatitis C (HCV). Here we report the outcomes of living donor recipients over the age of 60 years. Materials and Methods In 76 adult LDLT patients at our institution before September 2015, there were 21 recipients over 60 years old. We divided all of the recipients into 2 groups (“elderly” recipient group >60 years of age [n = 21], and a “nonelderly” recipient group Results The graft survival rates in the elderly group were 89.9% at 1 year, 89.9% at 3 years, 83.0% at 5 years, and 83.0% at 10 years. The graft survival rates in the nonelderly group was 91.1% at 1 year, 85.2% at 3 years, 82.8% at 5 years, and 82.9% at 10 year. There was no significant difference between the 2 age groups. In the elderly group, 3 patients died (2 patients had HCV recurrence and 1 patient had fungal infection in the brain, leading to a fatal subarachnoid hemorrhage). In the nonelderly group, 4 of 10 patients died of graft failure due to the graft size being too small. Conclusion Elderly patients, at the end stage of liver failure, are likely very frail and may have latent infections. Careful examination for latent infections before LDLT should be carefully performed in regard to indications for LDLT, which might reach satisfactory outcomes as in nonelderly LDLT recipients. Even if elderly patients are approved for transplantation, very careful management is needed. |
| Databáze: | OpenAIRE |
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