Pharmacological Stimulation of the Regenerative Capacity of Rat Testes Damaged by Paclitaxel
| Autor: | K. I. Ershov, Yu. A. Shchemerova, T. G. Borovskaya, V. E. Gol’dberg, P. G. Madonov, M. E. Poluektova, D. N. Kinsht, A. V. Vychuzhanina, A. M. Dygai |
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| Rok vydání: | 2014 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Testicular tissue Paclitaxel Population Granulocyte General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine Granulocyte Colony-Stimulating Factor Testis medicine Animals Regeneration Rats Wistar Spermatogenesis education education.field_of_study business.industry Regeneration (biology) Pharmacological stimulation General Medicine Spermatogonia Rats Granulocyte colony-stimulating factor medicine.anatomical_structure Endocrinology chemistry business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:773-775 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2446-8 |
| Popis: | Productivity of spermatogenesis and the population of spermatogonial cells were substantially reduced in male Wistar rats 3 months after administration of cytostatic drug paclitaxel, damaging stem spermatogonia. However, signs of reparative regeneration appeared in the testicular tissue. In animals receiving paclitaxel in combination with granulocyte CSF, the same period of observation, the number of spermatogonia and the effi ciency of spermatogenesis at the same terms of the study did not differ from those in intact animals. Intensive recovery processes started 1 month earlier than after administration of paclitaxel alone. These data attest to pronounced potentiating effect of granulocyte CSF on reparative regeneration of the testicular tissue. |
| Databáze: | OpenAIRE |
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