ZIKA VIRUS VERTICAL TRANSMISSION IN CHILDREN WITH CONFIRMED ANTENATAL EXPOSURE
| Autor: | Luana Damasceno, Leticia Guida, Genhong Cheng, Suan-Sin Foo, Elizabeth B. Brickley, Stephanie L. Gaw, Denise Cotrim da Cunha, Jae U. Jung, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira, Myrna C. Bonaldo, Liege Maria Abreu de Carvalho, Jose Paulo Pereira, Zilton Vasconcelos, Ieda Pereira Ribeiro, Claudia Raja Gabaglia, Andrea Zin, Lulan Wang, Irena Tsui, Patrícia Brasil, Mirza Rocha, Weiqiang Chen, James D. Cherry, Tara Kerin, Marcos Vinicius da Silva Pone, Saba Roghiyh Aliyari, Sheila Moura Pone, Kristina Adachi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
General Physics and Astronomy Physiology First year of life Diseases Urine Polymerase Chain Reaction law.invention Zika virus 0302 clinical medicine law Pregnancy Medicine 030212 general & internal medicine lcsh:Science reproductive and urinary physiology Polymerase chain reaction Pediatric Multidisciplinary biology Obstetrics Transmission (medicine) Zika Virus Infection 3. Good health In utero Virus Diseases Infectious diseases Female Infection medicine.medical_specialty Science Concordance Communicable Diseases General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Clinical Research 030225 pediatrics Humans business.industry General Chemistry Gold standard (test) Zika Virus Perinatal Period - Conditions Originating in Perinatal Period biology.organism_classification medicine.disease 030104 developmental biology Immunoglobulin M Viral infection Communicable disease transmission lcsh:Q business |
| Zdroj: | Nature Communications Nature communications, vol 11, iss 1 Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2041-1723 |
| DOI: | 10.1101/2020.02.26.20028399 |
| Popis: | We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015–2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities. Here, Brasil et al. investigate mother to child Zika virus (ZIKV) transmission rates in a large longitudinal cohort of pregnant ZIKV-positive women with their infants followed from the time of maternal infection through birth and onwards, finding high in utero transmission rates that do not predict clinical outcomes, suggesting follow-up of children with antenatal ZIKV exposure is necessary. |
| Databáze: | OpenAIRE |
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