Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
| Autor: | M B. Bracken, Elizabeth W. Triche, Kathleen Belanger, Kemp W. Bundy, Brian P. Leaderer, Janneane F. Gent, William S. Beckett |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Veterinary medicine Percentile Immunology Peak Expiratory Flow Rate Article medicine Odds Ratio Immunology and Allergy Humans Child Asthma biology business.industry Penicillium Odds ratio Environmental exposure Environmental Exposure biology.organism_classification medicine.disease Confidence interval Logistic Models VEMS Air Pollution Indoor Housing Female Mitosporic Fungi business Cladosporium |
| Popis: | Background Exposure to airborne fungi has been associated with increased airway hyperreactivity and asthma prevalence. Objective To investigate the association between common indoor fungi and airway hyperreactivity measured by peak expiratory flow variability in asthmatic children. Methods Children 6 to 12 years of age (n = 225) with a physician diagnosis of asthma were enrolled in the study to have their peak expiratory flow recorded twice daily during a 2-week period. Genus-specific, quantitative, in-home airborne mold concentrations were measured. Logistic regression models were used to examine the relationship between a mean peak expiratory flow variability greater than 18.5% (75th percentile) and any mold in the home (total mold, Cladosporium , Penicillium , Aspergillus , and Alternaria ). Results Mold was detected in 93% of the homes. The most common molds were Cladosporium in 72% and Penicillium in 42% of the samples. Controlling for sex, ethnicity, age, and winter season of sampling, Penicillium measured in the home was associated with a mean peak expiratory flow variability greater than 18.5% (odds ratio, 2.4; 95% confidence interval, 1.2–4.8). Greater peak expiratory flow variability was not associated with total mold or other mold measured in the home. Conclusion Exposure to airborne Penicillium is associated with increased peak expiratory flow variability in asthmatic children. |
| Databáze: | OpenAIRE |
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