| Autor: |
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1541-7786.22515802.v1 |
| Popis: |
Figure S1. Cellular phenotypes observed in response to ERK2 overexpression in A-375 cells. Figure S2. No paracrine effect was produced by cells dying due to knockdown of the essential gene PSMA3. Figure S3. A-375 xenograft tumors with ERK2 overexpression displayed necrosis and/or fibrosis. Figure S4. Paradoxical activation triggered by low doses of BRAFi in GR-M augmented the growth suppression caused by ERK2 overexpression. Figure S5. Graphical representations of vector constructs used in this study. Table S1. MSigDB Hallmark pathways that were significantly enriched in genes upregulated after 20 h treatment with doxycycline in A-375 ERK2 cells. Table S2. Transcription factor targets (from MSigDB C3 TFT) for known ERK targets were significantly enriched in genes upregulated after 20 h treatment with doxycycline in A-375 ERK2 cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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