Epidermal Growth Factor Receptor Gene Mutation in Pleural Lavage Cytology Findings of Primary Lung Adenocarcinoma Cases
| Autor: | Osamu Araki, Yoko Karube, Masayuki Chida, Yuji Matsumura, Satoru Kobayashi, Takashi Inoue, Sumiko Maeda |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pathology Lung Neoplasms DNA Mutational Analysis 030204 cardiovascular system & hematology Gene mutation Exon 0302 clinical medicine Japan Risk Factors Cytology Epidermal growth factor receptor Aged 80 and over integumentary system biology Gastroenterology Exons General Medicine Middle Aged ErbB Receptors Phenotype medicine.anatomical_structure 030220 oncology & carcinogenesis Adenocarcinoma Female Original Article Cardiology and Cardiovascular Medicine Adult Pulmonary and Respiratory Medicine medicine.medical_specialty Adenocarcinoma of Lung 03 medical and health sciences Biomarkers Tumor medicine Humans Genetic Predisposition to Disease Therapeutic Irrigation Lung cancer Aged Neoplasm Staging Retrospective Studies Lung business.industry medicine.disease respiratory tract diseases Egfr mutation Mutation biology.protein Surgery Neoplasm Grading business |
| Zdroj: | Annals of Thoracic and Cardiovascular Surgery. 24:1-5 |
| ISSN: | 2186-1005 1341-1098 |
| DOI: | 10.5761/atcs.oa.17-00088 |
| Popis: | Purpose In the present study, we examined the relationship between intraoperative pleural lavage cytology findings and presence of epidermal growth factor receptor (EGFR) gene mutations. Methods We investigated 160 patients who underwent surgical treatment for primary lung adenocarcinoma at our hospital from January 2011 to December 2013 to determine the presence of EGFR gene mutations and pleural lavage cytology. Results In all, 52 subjects (31.5%) were positive EGFR gene mutations, of whom 38 were found to possess the Exon 21 L858R mutation. Intraoperative pleural lavage cytology examinations were performed in 160 subjects and 12 had positive results, of whom 6 were positive for EGFR gene mutations, which was the Exon 21 L858R mutation in all. In a comparison between subjects possessing the Exon 21 L858R mutation and those negative for EGFR gene mutations, lavage cytology-positive (p = 0.02) and vascular infiltration-negative (p = 0.01) were characteristics of the Exon 21 L868R mutation-positive group. Conclusion Subjects positive for the EGFR Exon 21 L858R mutation had a higher positive rate of intraoperative pleural lavage cytology than those not possessing EGFR mutations. |
| Databáze: | OpenAIRE |
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