Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study
| Autor: | Chih-Yen Chien, Tai-Lin Huang, Hsuan-Ying Huang, Hsuan-Chih Hsu, Wen-Ling Tsai, Chun-Chung Lui, Hui-Chun Chen, Fu-Min Fang |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Longitudinal study Multivariate analysis medicine.medical_treatment Quality of life Internal medicine otorhinolaryngologic diseases medicine Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Stage (cooking) Survival rate Neoplasm Staging Radiation business.industry Cancer Nasopharyngeal Neoplasms Middle Aged medicine.disease humanities Surgery Radiation therapy Survival Rate Nasopharyngeal carcinoma Multivariate Analysis Quality of Life Regression Analysis Female Radiotherapy Intensity-Modulated Radiotherapy Conformal business |
| Zdroj: | International journal of radiation oncology, biology, physics. 72(2) |
| ISSN: | 0360-3016 |
| Popis: | Purpose To investigate the changes of quality of life (QoL) and survival outcomes for patients with nasopharyngeal carcinoma (NPC) treated by three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT). Methods and Materials Two hundred and three newly diagnosed NPC patients, who were curatively treated by 3D-CRT ( n = 93) or IMRT ( n = 110) between March 2002 and July 2004, were analyzed. The distributions of clinical stage according to American Joint Committee on Cancer 1997 were I: 15 (7.4%), II: 78 (38.4%), III: 74 (36.5%), and IV: 36 (17.7%). QoL was longitudinally assessed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H&N35 questionnaires at the five time points: before RT, during RT (36 Gy), and 3 months, 12 months, and 24 months after RT. Results The 3-year locoregional control, metastasis-free survival, and overall survival rates were 84.8%, 76.7%, and 81.7% for the 3D-CRT group, respectively, compared with 84.2%, 82.6%, and 85.4% for the IMRT group ( p value > 0.05). A general trend of maximal deterioration in most QoL scales was observed during RT, followed by a gradual recovery thereafter. There was no significant difference in most scales between the two groups at each time point. The exception was that patients treated by IMRT had a both statistically and clinically significant improvement in global QoL, fatigue, taste/smell, dry mouth, and feeling ill at the time point of 3 months after RT. Conclusions The potential advantage of IMRT over 3D-CRT in treating NPC patients might occur in QoL outcome during the recovery phase of acute toxicity. |
| Databáze: | OpenAIRE |
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