Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
Autor: | Robert Peaden, Kelli L. Vaughan, Tamzin A. Kaiser, Rafael de Cabo, R. Michael Anson, Julie A. Mattison |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Aging Calorie Rodent Longevity Calorie restriction Rodentia 03 medical and health sciences biology.animal Animals Macronutrient composition Medicine Caloric Restriction biology business.industry Caloric theory Rodent model Macaca mulatta Nonhuman primate 030104 developmental biology Evolutionary biology Models Animal Geriatrics and Gerontology Age of onset Energy Intake business |
Zdroj: | The Journals of Gerontology: Series A. 73:48-53 |
ISSN: | 1758-535X 1079-5006 |
Popis: | For a century, we have known that caloric restriction influences aging in many species. However, only recently it was firmly established that the effect is not entirely dependent on the calories provided. Instead, rodent and nonhuman primate models have shown that the rate of aging depends on other variables, including the macronutrient composition of the diet, the amount of time spent in the restricted state, age of onset, the gender and genetic background, and the particular feeding protocol for the control group. The field is further complicated when attempts are made to compare studies across different laboratories, which seemingly contradict each other. Here, we argue that some of the contradictory findings are most likely due to methodological differences. This review focuses on the four methodological differences identified in a recent comparative report from the National Institute on Aging and University of Wisconsin nonhuman primate studies, namely feeding regimen, diet composition, age of onset, and genetics. These factors, that may be influencing the effects of a calorie restriction intervention, are highlighted in the rodent model to draw parallels and elucidate findings reported in a higher species, nonhuman primates. |
Databáze: | OpenAIRE |
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