Enhanced MRI relaxivity of aquated Gd3+ ions by carboxyphenylated water-dispersed graphene nanoribbons

Autor:	Lon J. Wilson, Paolo Decuzzi, Feifei Qu, Raja Muthupillai, Ayrat Gizzatov, Vazrik Keshishian, James M. Tour, Ayrat M. Dimiev, Robert G. Bryant, Adem Guven
Rok vydání:	2014
Předmět:	Ions Materials science Nanotubes Carbon Carbon chemistry Gadolinium Contrast Media Water chemistry.chemical_element Conjugated system Photochemistry Magnetic Resonance Imaging Ion Nuclear magnetic resonance chemistry Water chemistry Graphite General Materials Science Graphene nanoribbons
Zdroj:	Nanoscale. 6:3059-3063
ISSN:	2040-3372 2040-3364
DOI:	10.1039/c3nr06026h
Popis:	The present study demonstrates that highly water-dispersed graphene nanoribbons dispersed by carboxyphenylated substituents and conjugated to aquated Gd(3+) ions can serve as a high-performance contrast agent (CA) for applications in T1- and T2-weighted magnetic resonance imaging (MRI) with relaxivity (r1,2) values outperforming currently-available clinical CAs by up to 16 times for r1 and 21 times for r2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5197f55135d3171946057c351ded884 https://doi.org/10.1039/c3nr06026h Zobrazit plný text záznamu