Isolation of a new compound, 2-butanone 4-glucopyranoside 6′-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb
| Autor: | Kaoru Umehara, Y. Wongkrajang, Suchitra Thongpraditchote, Hiroshi Noguchi, Somsak Nualkaew |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Stereochemistry Anti-Inflammatory Agents Memecylon edule Plant Science Methyl benzoate 01 natural sciences Biochemistry Anti-inflammatory Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Phenols medicine Humans Organic chemistry Epigallocatechin-3-O-gallate 2-butanone biology Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry Gallate biology.organism_classification 0104 chemical sciences Plant Leaves 030104 developmental biology Melastomataceae |
| DOI: | 10.6084/m9.figshare.4214226 |
| Popis: | This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6′-O-gallate (1) with eight known compounds, namely, 3,3′-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)–dihydromyricetin-4′-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9). All compounds were isolated for the first time from this plant. The major compounds (2, 3 and 5) exhibited significant anti-inflammatory activity. In conclusion, M. edule was recognised to be a good source for phenolic compounds and these compounds may contribute to anti-inflammatory activity of the extract. |
| Databáze: | OpenAIRE |
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