The Effects of Whole-body Irradiation on the Serum Levels and Kinetics of Thyroid Hormones in Rats
| Autor: | J.S. Orr, W.M. Gray, W.A. Ratcliffe |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Radiological and Ultrasound Technology Chemistry Thyroid Kinetics Whole body irradiation General Medicine Anorexia Endocrinology medicine.anatomical_structure Internal medicine Thyroid hormones medicine Distribution (pharmacology) Radiology Nuclear Medicine and imaging Irradiation medicine.symptom Hormone |
| Zdroj: | International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 37:653-666 |
| ISSN: | 0020-7616 |
| Popis: | SummaryThe effects of a single whole-body dose of X-rays on the serum levels and kinetics of thyroid hormones in rats were studied. The influence of radiation-induced anorexia was monitored by using pair fed control groups. A dose of 800 rad caused a reduction in T4 levels and 750 rad had a similar effect on T3; in each case the control group showed a smaller reduction. The kinetic results indicated that, in the control groups, the early reduction in hormone concentrations was caused by decreased production, whereas, in the irradiated groups, it was caused by a change in the distribution of the hormone; however, the continuing reduction in hormone levels in the irradiated rats appeared to result from decreased production. The results suggest that the thyroid system may play an active part in the early metabolic changes which follow whole-body irradiation. |
| Databáze: | OpenAIRE |
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