The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases

Autor:	Fuad A. Iraqi, Hanifa Abu Toamih Atamni, Aysar Nashef
Rok vydání:	2018
Předmět:	0301 basic medicine Collaborative Cross Mice Genotype Population Quantitative Trait Loci Genome-wide association study Quantitative trait locus Biology Communicable Diseases 03 medical and health sciences Mice Inbred strain Gene mapping Genetic variation Genetics Genetic predisposition Animals Humans Genetic Predisposition to Disease education Crosses Genetic Genetic diversity education.field_of_study Genetic Variation Genomics Disease Models Animal 030104 developmental biology Phenotype Host-Pathogen Interactions Genome-Wide Association Study
Zdroj:	Mammalian genome : official journal of the International Mammalian Genome Society. 29(7-8)
ISSN:	1432-1777
Popis:	Infectious diseases, also known as communicable diseases, refer to a full range of maladies caused by pathogen invasion to the host body. Host response towards an infectious pathogen varies between individuals, and can be defined by responses from asymptomatic to lethal. Host response to infectious pathogens is considered as a complex trait controlled by gene–gene (host–pathogen) and gene–environment interactions, leading to the extensive phenotypic variations between individuals. With the advancement of the human genome mapping approaches and tools, various genome-wide association studies (GWAS) were performed, aimed at mapping the genetic basis underlying host susceptibility towards infectious pathogens. In parallel, immense efforts were invested in enhancing the genetic mapping resolution and gene-cloning efficacy, using advanced mouse models including advanced intercross lines; outbred populations; consomic, congenic; and recombinant inbred lines. Notwithstanding the evident advances achieved using these mouse models, the genetic diversity was low and quantitative trait loci (QTL) mapping resolution was inadequate. Consequently, the Collaborative Cross (CC) mouse model was established by full-reciprocal mating of eight divergent founder strains of mice (A/J, C57BL/6J, 129S1/SvImJ, NOD/LtJ, NZO/HiLtJ, CAST/Ei, PWK/PhJ, and WSB/EiJ) generating a next-generation mouse genetic reference population (CC lines). Presently, the CC mouse model population comprises a set of about 200 recombinant inbred CC lines exhibiting a unique high genetic diversity and which are accessible for multidisciplinary studies. The CC mouse model efficacy was validated by various studies in our lab and others, accomplishing high-resolution (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d516795656e420345ef8c377befd977a https://pubmed.ncbi.nlm.nih.gov/30143822 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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