Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients
| Autor: | Mona Youssry Helmy, Laila A. Rashed, Hala Ibrahim El Gendy, Noha Adly Sadik |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Endocrinology Diabetes and Metabolism T2DM 030209 endocrinology & metabolism Calcitriol receptor lcsh:Diseases of the endocrine glands. Clinical endocrinology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Vitamin D and neurology Medicine 030212 general & internal medicine Vitamin D Glycemic Creatinine lcsh:RC648-665 biology business.industry Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease FokI chemistry biology.protein Gene polymorphism business VDR gene polymorphism Research Paper |
| Zdroj: | Journal of Clinical & Translational Endocrinology Journal of Clinical & Translational Endocrinology, Vol 15, Iss, Pp 25-29 (2019) |
| ISSN: | 2214-6237 |
| Popis: | Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Methods: 50 patients with T2DM and 50 healthy age matched control subjects were enrolled. FBG, 2 h –PPG, fasting lipids, Hb A1c, calcium, phosphorus, urea, creatinine, ALT, AST were measured. BMI has calculated. Serum 25 hydroxy vitamin D [25(OH)D] has measured by ELISA. VDR gene polymorphisms detection has done by polymerase chain reaction through restriction fragment length polymorphism (PCR-RFLP) technique. Results: Our study has shown lower mean levels of 25(OH)D in patients with T2DM (28.54 ± 10.02) in comparison with control subjects (44.65 ± 7.19), p |
| Databáze: | OpenAIRE |
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