Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy
| Autor: | Andrew T. Chan, Robert Hoepner, Christian Brandt, Corrado Bernasconi, Ralf Gold, G. Classen, C. Classen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Neurology Encephalopathy 610 Medicine & health Electroencephalography 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Natalizumab Multiple Sclerosis Relapsing-Remitting Virology medicine Humans Immunologic Factors Retrospective Studies medicine.diagnostic_test business.industry Progressive multifocal leukoencephalopathy Multiple sclerosis Leukoencephalopathy Progressive Multifocal Middle Aged medicine.disease Quantitative electroencephalography Prognosis JC Virus 030104 developmental biology Female Virus Activation Neurology (clinical) Radiology Complication business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Classen, G.; Classen, C.; Bernasconi, Corrado Angelo; Brandt, C.; Gold, R.; Chan, Andrew; Hoepner, Robert (2019). Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy. Journal of neurovirology, 25(1), pp. 133-136. Springer 10.1007/s13365-018-0689-2 |
| ISSN: | 1538-2443 |
| DOI: | 10.1007/s13365-018-0689-2 |
| Popis: | Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes. |
| Databáze: | OpenAIRE |
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