Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa: Findings from the Stroke Investigative Research and Educational Network (SIREN) study

Autor: Abiodun M. Adeoye, Adeseye A. Akintunde, Joshua Akinyemi, Adekunle G. Fakunle, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Onoja Akpa, Oyedunni Arulogun, Akinkunmi P. Okekunle, Okechukwu S. Ogah, Carolyn Jenkins, Godwin Ogbole, Hemant K. Tiwari, Osahon J. Asowata, Philip Ibinaiye, Lambert Appiah, Atinuke M. Agunloye, Joseph Yaria, Benedict Calys-Tagoe, Obiageli U. Agbogu-Ike, Sunday Adeniyi, Philip Adebayo, Olayemi Balogun, Olajumoke Aderonmu, Oluwayemisi T. Adeegbe, Oladimeji Adebayo, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Neurological Sciences. 441:120360
ISSN: 0022-510X
DOI: 10.1016/j.jns.2022.120360
Popis: The prognostic implications of metabolic syndrome (METS) among African stroke patients are poorly understood. This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study.We included stroke cases (adults aged18 years with CT/MRI confirmed stroke). The validated tools comprehensively evaluated vascular, lifestyle, and psychosocial factors. We used logistic regression to estimate adjusted odds ratios (OR) with 95% CIs for the association between METS and risk factors. We also computed the prediction power of the domain of covariates in a sequential manner using the area under the receiver operating curve (ROC) curve.Among 3998 stroke subjects enrolled in the study, 76.8% had METS by at least one of the clinical definitions. Factors associated with METS were age 50 years (OR- 1.46, CI-1.19-1.80), male gender (OR 4.06, CI- 3.28-5.03), income100USD (OR1.42, CI-1.17-1.71), stress (OR1.46, CI-1.14-1.87), family history of diabetes mellitus (OR1.38, CI-1.06-1.78), and cardiac disease (OR1.42, CI-1.18-1.65). Stroke severity was higher among those with METS (SLS = 5.8 ± 4.3) compared with those without METS (6.2 ± 4.5) at p = 0.037. METS was associated with higher odds (aOR 1.31, CI-1.08-1.58) of one-month fatality after adjusting for stroke severity, age 50 years, and average monthly income100USD.METS is very common among African stroke patients and is associated with stroke severity and worse one-month fatality. Lifestyle interventions may prevent METS and attenuate its impact on stroke occurrence and outcomes.
Databáze: OpenAIRE
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