Local immune inflammatory response to infected total hip and knee replacements
| Autor: | Dan Nordström, I. Antti-Poika, Seppo Santavirta, Yrjö T. Konttinen |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Reoperation medicine.drug_class Connective tissue Periprosthetic Inflammation Monoclonal antibody Major histocompatibility complex Peripheral blood mononuclear cell Immunoenzyme Techniques 03 medical and health sciences Leukocyte Count 0302 clinical medicine Immune system Antigens CD medicine Humans Surgical Wound Infection Orthopedics and Sports Medicine Aged 030222 orthopedics Immunity Cellular biology business.industry Foreign-Body Reaction 030229 sport sciences General Medicine Middle Aged Staphylococcal Infections medicine.disease 3. Good health Prosthesis Failure medicine.anatomical_structure Connective Tissue Immunology biology.protein Surgery Female Hip Prosthesis medicine.symptom business Knee Prosthesis Infiltration (medical) |
| Zdroj: | Archives of orthopaedic and trauma surgery. 113(3) |
| ISSN: | 0936-8051 |
| Popis: | We studied the tissue response for periprosthetic pseudosynovial tissue in seven patients with a purulent endoprosthetic infection and six patients with common prosthesis loosening, using specific monoclonal antibodies in avidin-biotin-peroxidase complex staining. In infected cases, proline 4-hydroxylase positive fibroblasts dominated the stroma of the vascularized periprosthetic connective tissue, whereas ;diffuse local infiltrations of mononuclear cells characterized the cellular histological overview. Local cellular response consisted of CD11b and MHC locus II antigen-positive immunoreactive monocytes/macrophages and of T lymphocytes, mostly of the CD4 subset. Only a few CD25-positive cells could be detected. The local cellular response in six patients with prosthesis loosening of nonbacterial origin was mild, showing a sparse perivascular infiltration of CD11b- and Ia-positive monocytes/macrophages and CD4/CD8-positive T lymphocytes in a proportion of 2:1. Only occasional CD15- or lactoferrin-positive neutrophils and CD25-positive lymphocytes could be detected. Our results from chronically infected joint replacements suggest that neutrophils, being virtually absent in the tissue compartment, do not contribute to pathological events in the “pseudojoint” cavity, whereas local tissue response consists of a mononuclear inflammatory cell reaction of a macrophage-dependent foreign-body type. |
| Databáze: | OpenAIRE |
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