A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability
| Autor: | Malek Adjouadi, Ranjan Duara, Russell M. Bauer, Aldrich Chan, Steven T. DeKosky, Gabriel Lizarraga, Jordi A. Matías-Guiu, Maria T. Greig-Custo, Mercedes Cabrerizo, Ailyn Penate, Rosie E. Curiel Cid, Monica Rosselli, David A. Loewenstein, Daema Piña, Todd E. Golde |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Precuneus Disease lcsh:Geriatrics Audiology behavioral disciplines and activities lcsh:RC346-429 Semantic interference 03 medical and health sciences 0302 clinical medicine Cognitive assessment Cognitive stress mental disorders medicine Generalizability theory 10. No inequality Association (psychology) lcsh:Neurology. Diseases of the nervous system 030304 developmental biology 0303 health sciences Diversity business.industry Mild cognitive impairment Cognition Entorhinal cortex Test (assessment) Prodromal Alzheimer's disease lcsh:RC952-954.6 Psychiatry and Mental health medicine.anatomical_structure Cognitive & Behavioral Assessment Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 550-559 (2019) |
| ISSN: | 2352-8729 |
| Popis: | Introduction Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer's disease are needed. Methods Performance of Hispanic and non-Hispanic older adults on the Loewenstein-Acevedo Scale of Semantic Interference and Learning (LASSI-L) was examined in persons with amnestic mild cognitive impairment (aMCI) or normal cognition. The association between a novel cognitive marker, the failure to recover from proactive semantic interference (frPSI), and cortical thinning was explored. Results English-speaking aMCI participants scored lower than cognitively normal participants on all LASSI-L indices, while Spanish-speaking aMCI participants scored lower in learning, frPSI, and delayed recall. Healthy controls obtained equivalent scores on all indices except retroactive semantic interference. English-speaking and Spanish-speaking aMCI participants had equivalent scores except English speaker's greater vulnerability to frPSI. Across aMCI groups, frPSI was associated with cortical thinning of the entorhinal cortex and precuneus (r = −0.45 to r = 0.52; P Highlights • Culturally fair outcome measures sensitive to detecting prodromal Alzheimer's disease are needed. • The Loewenstein-Acevedo Scale of Semantic Interference and Learning differentiates amnestic mild cognitive impairment from cognitively normal Hispanic elderly, a growing minority group. • A sensitive marker, failure to recover from proactive semantic interference, was implicated in amnestic mild cognitive impairment, regardless of culture/language. • The failure to recover from proactive semantic interference was associated with cortical thinning in Alzheimer's disease–prone regions. |
| Databáze: | OpenAIRE |
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