Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
| Autor: | Juan Martínez-Henández, Jesús Pintor, Alfonso J. Cruz-Jentoft, Fernando Huete-Toral, Almudena Crooke, Joaquin Martinez-Lopez |
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| Rok vydání: | 2017 |
| Předmět: |
Bioquímica
0301 basic medicine lcsh:Immunologic diseases. Allergy Aging medicine.medical_specialty Immunology Short Report Adenosine A2A receptor Biology lcsh:Geriatrics 03 medical and health sciences Immune system Internal medicine Gene expression medicine Centenarian Receptor Adenosine receptor Adenosine Geriatría lcsh:RC952-954.6 Ageing 030104 developmental biology Endocrinology Ecto-nucleotidase lcsh:RC581-607 medicine.drug |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Immunity & Ageing, Vol 14, Iss 1, Pp 1-5 (2017) E-Prints Complutense. Archivo Institucional de la UCM instname E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid Immunity & Ageing : I & A |
| Popis: | Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we detected two subgroups of centenarians with high and low level of transcript. Additionally, adenosine A2A receptor mRNA level of centenarians, did not correlate with their cognitive impairment. In summary, our pilot study suggests that unlike of adenosine A2A receptor, the level of CD39 as well as CD73 mRNA could be a hallmark of successful human ageing. Electronic supplementary material The online version of this article (doi:10.1186/s12979-017-0094-3) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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