The Effects of Thiazide Diuretics on Calcium Metabolism in the Aged
| Autor: | H. Mitchell Perry, Fran E. Kaiser, Michael Horowitz, Judy Jensen, John E. Morley, Horace M. Perry |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty medicine.medical_treatment Osteocalcin Biological Availability Parathyroid hormone Sex Factors Internal medicine Prevalence Humans Medicine Testosterone Thiazide Aged Aged 80 and over Calcium metabolism biology Hydroxycholecalciferols business.industry Age Factors Chlorthalidone Cross-Sectional Studies Endocrinology Parathyroid Hormone biology.protein Drug Evaluation Female Bone Diseases Geriatrics and Gerontology Diuretic business medicine.drug |
| Zdroj: | Journal of the American Geriatrics Society. 41:818-822 |
| ISSN: | 0002-8614 |
| DOI: | 10.1111/j.1532-5415.1993.tb06176.x |
| Popis: | Objective: To determine the effects of long-term use of the thiazide diuretic chlorthalidone on serum bone-related biochemical variables in older persons. Design: Cross-sectional comparison. Setting: Community-dwelling subjects who had participated in the Systolic Hypertension in the Elderly (SHEP) program. Participants: Sixty-six Caucasians (36 male and 30 female), age range 70 to 89 years, of whom 23 were taking a thiazide diuretic. Measurements: 25-hydroxyvitamin D (25OHD), parathyroid hormone, osteocalcin, calcitonin, and serum bioavailable testosterone. Results: In both groups, there was a high prevalence of low 25 (OHD) levels (30%). Log 25OHD showed a significant inverse relationship to parathyroid hormone (r = .33, P < 0.05). Thiazide users had lower levels of osteocalcin (P < 0.05) and parathyroid hormone levels (P < 0.05) compared with non-thiazide users. Male thiazide users had decreased bioavailable testosterone levels compared with non-thiazide users (P < 0.05). Serum osteocalcin was significantly related to bioavailable testosterone in men not on thiazide (r = .43, P < 0.05). Conclusions: Hypovitaminosis D is a common finding in older individuals with associated elevations in parathyroid hormone. Parathyroid hormone and testosterone concentration (in men) are correlated with serum osteocalcin, a measure of osteoblastic activity. Long-term thiazide use alters these relationships and produces a biochemical profile suggestive of decreased bone formation. Reduced bioavailable testosterone may also play a role in these biochemical changes. |
| Databáze: | OpenAIRE |
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