Analgesia scores as timed responses following oral administration of propoxyphene to postpartum patients
| Autor: | Robert L. Wolen, Arthur Baptisti, Charles M. Gruber |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Hydrochloride
Propoxyphene Administration Oral Naphthalenes Toxicology Placebo Placebos chemistry.chemical_compound Chlorides Pregnancy Oral administration Humans Medicine Muscle Cramp Uterine Diseases Pharmacology Analysis of Variance Clinical Trials as Topic Dextropropoxyphene business.industry Puerperal Disorders chemistry Anesthesia Female Salts Analgesia Sulfonic Acids business medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 19:504-511 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(71)90009-3 |
| Popis: | Two propoxyphene salts, the hydrochloride and the napsylate, were administered in equimolar quantities as single oral doses to women reporting postpartum uterine cramping. The double-blind doses included 32, 65, and 130 mg of the hydrochloride and 50, 100, and 200 mg of the napsylate salt. Identical-appearing placebo capsules were included. Grouping the patients according to the intensity of pain treated and assigning paired patients to different treatment groups was an important part of the procedure. The results (analgesia scores) indicate a linear dose-response over this range and no significant differences between the propoxyphene salts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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