Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes

Autor:	Gerard G M D'Souza, Mark Böhlke, Ahmed S. Mehanna, Shrey Shah, Parul Benien, Mohammed Almuteri
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Liposome Biochemistry Chemistry Bilayer Phospholipid Molecule Surface modification Ligand (biochemistry) Combinatorial chemistry Conjugate
Zdroj:	Methods in Molecular Biology ISBN: 9781071612613 Methods in Molecular Biology Methods in Molecular Biology ISBN: 9781493922871
Popis:	Surface modification of liposomes with a ligand is facilitated by the conjugation of the ligand to a hydrophobic molecule that serves to anchor the ligand to the liposomal bilayer. We describe here a simple protocol to conjugate a triphenylphosphonium group to several commercially available functionalized phospholipids. The resulting triphenylphosphonium-conjugated lipids can be used to prepare liposomes that preferentially associate with mitochondria when exposed to live mammalian cells in culture.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d511fbc3e7edddb8444e263992290301 https://doi.org/10.1007/978-1-0716-1262-0_7 Zobrazit plný text záznamu