Increasing survival of hepatocellular carcinoma patients in Scotland: a review of national cancer registry data
| Autor: | John F. Dillon, David H. Brewster, O. James Garden, John K. Dunbar |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Male medicine.medical_specialty Carcinoma Hepatocellular Alcohol Drinking Treatment outcome Risk Factors Internal medicine medicine Humans Registries skin and connective tissue diseases Survival rate Aged Gynecology Aged 80 and over Hepatology business.industry Incidence (epidemiology) Incidence Liver Neoplasms Gastroenterology Original Articles Middle Aged medicine.disease digestive system diseases Cancer registry Survival Rate Treatment Outcome Scotland Hepatocellular carcinoma Female sense organs business |
| Zdroj: | HPB : the official journal of the International Hepato Pancreato Biliary Association. 15(4) |
| ISSN: | 1477-2574 |
| Popis: | ObjectivesThis study describes changes in the survival of patients with hepatocellular carcinoma (HCC) registered with the Scottish Cancer Registry between 1985 and 2008.MethodsData on patients diagnosed with HCC were extracted from the Scottish Cancer Registry, along with linked data on treatment and risk factors for liver disease. One‐, 3‐ and 5‐year relative survival rates were calculated for each time period and a Cox regression model was used to assess the impact of prior admissions on survival.ResultsThe incidence of HCC increased between 1985 and 2008. The proportion of patients with prior alcohol‐related admissions rose over the time period studied from 16.0% to 27.1%. Five‐year relative survival increased in women between 1985–1989 and 2005–2007 from 0.5% [95% confidence interval (CI) 0.0–3.7] to 10.6% (95% CI 5.2–18.1). In men, 5‐year relative survival increased from 0.4% (95% CI 0.2–2.2) to 4.4% (95% CI 1.5–9.9). Regression analysis showed that older age, history of alcohol‐related admissions and deprivation were associated with lower survival, and hospitalization for viral hepatitis was associated with higher survival.conclusionsAgainst the background of an increasing incidence of HCC in Scotland, survival times have increased substantially. |
| Databáze: | OpenAIRE |
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