IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
| Autor: | Vera Makar, Paul M. Bojczuk, James Witek, Peter D. Katsikis, Yvonne M. Mueller |
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| Rok vydání: | 2002 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cytotoxicity Immunologic Adolescent Immunology Apoptosis HIV Infections CD8-Positive T-Lymphocytes Lymphocyte Activation CCL5 Interleukin 21 Immunology and Allergy Cytotoxic T cell Humans IL-2 receptor fas Receptor Antigen-presenting cell Child Interleukin 3 Interleukin-15 Chemistry ZAP70 General Medicine Natural killer T cell Cell biology Child Preschool T-Lymphocytes Cytotoxic |
| Zdroj: | International immunology. 15(1) |
| ISSN: | 0953-8178 |
| Popis: | Although the effect of IL-15 has been described on murine cells in vitro and in vivo, its effect on human memory CD8(+) T cells is not well characterized. We show here that IL-15 preferentially enhances the activation and effector function of human effector-memory CD45RA(-)CD62L(-) and CD45RA(+)CD62L(-) CD4(+) and CD8(+) T cells in both healthy and HIV-infected individuals. We find that IL-15 increases 2- to 5-fold both the activation and secretion of the effector cytokines IFN-gamma and tumor necrosis factor (TNF)-alpha by anti-CD3-stimulated purified CD4(+) and CD8(+) T cells and peripheral blood mononuclear cells from healthy and HIV-infected individuals. Furthermore, IL-15 potently inhibits CD95/Fas-induced apoptosis of the effector-memory CD4(+) and CD8(+) T cells from HIV-infected individuals. These findings suggest that in addition to being a growth and survival factor for memory CD8(+) T cells, IL-15 is also a potent activator of human effector-memory CD8(+) T cells both in healthy and in HIV-infected individuals. |
| Databáze: | OpenAIRE |
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