Multiple Micronutrient Supplementation Improves Anemia, Micronutrient Nutrient Status, and Growth of Vietnamese Infants: Double-Blind, Randomized, Placebo-Controlled Trial
| Autor: | Jacques Berger, Le Thi Hop |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Anemia Population Nutritional Status Tocopherols Medicine (miscellaneous) Riboflavin Growth Placebos chemistry.chemical_compound Animal science Double-Blind Method medicine Humans Micronutrients Vitamin A education education.field_of_study Nutrition and Dietetics biology business.industry Infant Iron deficiency medicine.disease Micronutrient Surgery Ferritin Zinc Vietnam chemistry Dietary Supplements biology.protein Zinc deficiency Female Infant Food Energy Intake business |
| Zdroj: | The Journal of Nutrition. 135:660S-665S |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/135.3.660s |
| Popis: | A randomized, double-blind, placebo-controlled trial was performed to assess the efficacy of different micronutrient supplementation regimes for improving micronutrient status, preventing anemia, and growth faltering of Vietnamese infants. A population-based sample of 306 infants aged 6-12 mo, split in 4 treatment groups, received daily multiple micronutrient (DMM), daily placebo (P), weekly multiple micronutrient (WMM), or daily iron (DI) supplements for 6 mo, 7 d/wk, under supervision. Weight and length were measured monthly, and anemia and plasma levels of ferritin, zinc, riboflavin, retinol, tocopherol, and homocysteine were determined before and after the supplementation. Z-scores for length-for-age and weight-for-age worsened significantly in all groups, but the length-for-age Z-score decreased significantly less in the DMM group (-0.32 +/- 0.05) than in the P and WMM groups (-0.49 +/- 0.05 and -0.51 +/- 0.05, respectively, P = 0.001). Hemoglobin levels increased significantly more in the DMM group [mean (95%CI): 16.4 g/L (12.4-20.4)] than in the P group [8.6 g/L (5.0-12.2), P = 0.04), with intermediate nonsignificant increases in the WMM [15.0 g/L (11.5-18.5)] and the DI [12.9 g/L (8.4-17.3)] groups. Ferritin changes were significantly greater in DMM (12.1 microg/L) and DI (9.5 microg/L) than in P (-14.7 microg/L) and WMM groups (-9.7 microg/L). Of the other micronutrients, only tocopherol showed a significantly greater level in the DMM group compared with P. Anemia still affected a quarter and zinc deficiency affected a third of infants although there was no iron deficiency after 6 mo of supplementation with DMM, suggesting that multiple factors are causing anemia and that the dose of zinc is too small. |
| Databáze: | OpenAIRE |
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