C-Reactive Protein Is an Independent Predictor of Mortality in Women With HIV-1 Infection
| Autor: | Jack DeHovitz, Philip Goldwasser, Howard Minkoff, Susan Holman, Joseph G. Feldman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Lymphocyte Serum albumin HIV Infections Gastroenterology Cohort Studies Internal medicine Immunopathology medicine Humans Pharmacology (medical) Proportional Hazards Models biology C-reactive protein Acute-phase protein Prognosis biology.organism_classification Survival Analysis C-Reactive Protein Infectious Diseases medicine.anatomical_structure Lentivirus Immunology HIV-1 biology.protein Female New York City Viral disease Body mass index Biomarkers |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 32:210-214 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/00126334-200302010-00014 |
| Popis: | The relationship of C-reactive protein (CRP) to mortality was assessed in 209 HIV-1-infected women after adjusting for age, body mass index (BMI), serum albumin, CD4 cell lymphocyte count, and HIV-1 RNA. During the follow-up period of up to 5 years (median = 45 months) there were 49 deaths. CRP at study enrollment was measured using a low sensitivity assay. CRP levels were only weakly correlated (Pearson correlation coefficient r < .2) with other predictors of mortality. CRP was a powerful predictor of mortality (p < .01) after adjusting for age, BMI, serum albumin, CD4 cell lymphocytes, and HIV-1 RNA. The relative hazard associated with an elevated CRP level, independent of the covariates noted above, varied from 3.4- to 13.6-fold depending on how CRP values were grouped. CRP may be a useful and inexpensive predictor of HIV disease mortality in women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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