An Eighteen-Month Helicobacter Infection Does Not Induce Amyloid Plaques or Neuroinflammation in Brains of Wild Type C57BL/6J Mice
| Autor: | Philippe Lehours, Valérie S. Fénelon, Claire Roubaud Baudron, Alban Giese, Lucie Chambonnier, Yoon H. Cho, Nathalie Salles, Francis Mégraud, Lucie Blaszczyk, Alice Buissionnière, Nathalie Macrez, Christine Varon, Pierre Dubus |
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| Přispěvatelé: | Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Histologie et Pathologie Moléculaire, Université Bordeaux Segalen - Bordeaux 2, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Physiopathologie de la plasticité neuronale, Infection à helicobacter, inflammation et cancer, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Physiopathologie du cancer du foie |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Neuroimmunomodulation [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Plaque Amyloid Inflammation Helicobacter Infections chemistry.chemical_compound medicine Animals Helicobacter Neuroinflammation ComputingMilieux_MISCELLANEOUS Amyloid beta-Peptides Helicobacter pylori biology General Neuroscience Wild type Brain General Medicine biology.organism_classification 3. Good health Mice Inbred C57BL Disease Models Animal Psychiatry and Mental health Clinical Psychology chemistry Immunology Helicobacter felis Immunohistochemistry Thioflavin Geriatrics and Gerontology medicine.symptom |
| Zdroj: | Journal of Alzheimer's Disease Journal of Alzheimer's Disease, IOS Press, 2015, 45 (4), pp.1045-1050. ⟨10.3233/JAD-143129⟩ |
| ISSN: | 1387-2877 |
| DOI: | 10.3233/JAD-143129⟩ |
| Popis: | There is increasing evidence to support the role of infectious agents in the progression of Alzheimer's disease (AD), especially Helicobacter pylori (H. pylori). The impact of Helicobacter infection on the brain of non-AD predisposed mice was studied. For that, C57BL/6J mice were infected by oral gavage with H. pylori SS1 (n = 6) and Helicobacter felis (H. felis) (n=6) or not infected (n = 6) for evaluation of neuroinflammation (anti-GFAP and anti-iba1 immunohistochemistry) and amyloid-β deposition (thioflavin-S stain and anti-Aβ immunohistochemistry). After 18-month of infection, H. pylori SS1 and H. felis infection induced a strong gastric inflammation compared to non-infected mice, but did not induce brain neuroinflammation or amyloid-β deposition. |
| Databáze: | OpenAIRE |
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