Electrophysiologic Effects of Growth Hormone Post-Myocardial Infarction

Autor: Konstantinos V Stamatis, Evangelos P. Daskalopoulos, Theofilos M. Kolettis, Marianthi Kontonika
Přispěvatelé: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
Hemodynamics
structural remodeling
Review
030204 cardiovascular system & hematology
Ventricular tachycardia
Catalysis
Sudden cardiac death
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Fibrosis
Internal medicine
medicine
Animals
Humans
Myocardial infarction
cardiovascular diseases
Physical and Theoretical Chemistry
ventricular tachyarrhythmias
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Ventricular Remodeling
business.industry
Human Growth Hormone
Organic Chemistry
General Medicine
medicine.disease
Computer Science Applications
Electrophysiological Phenomena
030104 developmental biology
myocardial infarction
lcsh:Biology (General)
lcsh:QD1-999
Coronary occlusion
Heart failure
Ventricular fibrillation
growth hormone
Cardiology
cardiovascular system
electrophysiologic remodeling
Tachycardia
Ventricular
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3, p 918 (2020)
International Journal of Molecular Sciences, Vol. 21, no. 3, p. 918 [1-16] (2020)
ISSN: 1422-0067
Popis: Myocardial infarction remains a major health-related problem with significant acute and long-term consequences. Acute coronary occlusion results in marked electrophysiologic alterations that can induce ventricular tachyarrhythmias such as ventricular tachycardia or ventricular fibrillation, often heralding sudden cardiac death. During the infarct-healing stage, hemodynamic and structural changes can lead to left ventricular dilatation and dysfunction, whereas the accompanying fibrosis forms the substrate for re-entrant circuits that can sustain ventricular tachyarrhythmias. A substantial proportion of such patients present clinically with overt heart failure, a common disease-entity associated with high morbidity and mortality. Several lines of evidence point toward a key role of the growth hormone/insulin-like growth factor-1 axis in the pathophysiology of post-infarction structural and electrophysiologic remodeling. Based on this rationale, experimental studies in animal models have demonstrated attenuated dilatation and improved systolic function after growth hormone administration. In addition to ameliorating wall-stress and preserving the peri-infarct myocardium, antiarrhythmic actions were also evident after such treatment, but the precise underlying mechanisms remain poorly understood. The present article summarizes the acute and chronic actions of systemic and local growth hormone administration in the post-infarction setting, placing emphasis on the electrophysiologic effects. Experimental and clinical data are reviewed, and hypotheses on potential mechanisms of action are discussed. Such information may prove useful in formulating new research questions and designing new studies that are expected to increase the translational value of growth hormone therapy after acute myocardial infarction.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje