| Autor: |
Mina Aziz, Tal Schechter, Steven Kowalyk, Pietro Merli, Hannah K. Choe, Wolf Rösler, Muna Qayed, Aaron Etra, George Morales, Jung-Yi Lin, Rainer Ordemann, Hannah Major-Monfried, Keith Sigel, Matthias Wölfl, John E. Levine, Karamjeet S. Sandhu, Michael A. Pulsipher, Umut Ozbek, Alexander B. Karol, Stephan Mielke, William J. Hogan, Ran Reshef, Francis Ayuk, James L.M. Ferrara, Elizabeth O. Hexner, Daniela Weber, Stelios Kasikis, Rachel Young, Jay Shah, Carrie L. Kitko, Kitsada Wudhikarn, Kaitlyn Ben-David, Hrishikesh K. Srinagesh, Zachariah DeFilipp, Matthew J. Hartwell, Stephan A. Grupp, Urvi Kapoor, Pavan Reddy |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
The Mount Sinai Acute GVHD International Consortium (MAGIC) algorithm probability (MAP), derived from 2 serum biomarkers, measures damage to crypts in the gastrointestinal tract during graft-versus-host disease (GVHD). We hypothesized that changes in MAP after treatment could validate it as a response biomarker. We prospectively collected serum samples and clinical stages of acute GVHD from 615 patients receiving hematopoietic cell transplantation in 20 centers at initiation of first-line systemic treatment and 4 weeks later. We computed MAPs and clinical responses and compared their abilities to predict 6-month nonrelapse mortality (NRM) in the validation cohort (n = 367). After 4 weeks of treatment, MAPs predicted NRM better than the change in clinical symptoms in all patients and identified 2 groups with significantly different NRM in both clinical responders (40% vs 12%, P < .0001) and nonresponders (65% vs 25%, P < .0001). MAPs successfully reclassified patients for NRM risk within every clinical grade of acute GVHD after 4 weeks of treatment. At the beginning of treatment, patients with a low MAP that rose above the threshold of 0.290 after 4 weeks of treatment had a significant increase in NRM, whereas patients with a high MAP at onset that fell below that threshold after treatment had a striking decrease in NRM that translated into clear differences in overall survival. We conclude that a MAP measured before and after treatment of acute GVHD is a response biomarker that predicts long-term outcomes more accurately than change in clinical symptoms. MAPs have the potential to guide therapy for acute GVHD and may function as a useful end point in clinical trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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