Are particular Epstein-Barr virus strains linked to disease?
| Autor: | Peter J. Jenkins, Paul J. Farrell |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cancer Research
Herpesvirus 4 Human Genes Viral Population medicine.disease_cause Defective virus Herpesviridae Virus Viral Matrix Proteins Species Specificity otorhinolaryngologic diseases medicine Gammaherpesvirinae Humans education education.field_of_study Polymorphism Genetic biology Defective Viruses Oncogene Proteins Viral biology.organism_classification medicine.disease Virology Epstein–Barr virus stomatognathic diseases Nasopharyngeal carcinoma Epstein-Barr Virus Nuclear Antigens Carrier State Burkitt's lymphoma Gene Deletion |
| Zdroj: | Seminars in cancer biology. 7(4) |
| ISSN: | 1044-579X |
| Popis: | The presence of the well-established EBV types (type 1 and 2) in cancers seems merely to reflect their prevalence in the population; the EBNA genes which determine type 1 and 2 are not usually expressed in cancers. In contrast, LMP1 is frequently expressed in nasopharyngeal carcinoma and a variant form of LMP1 has been linked with this disease. This form of LMP1 is also more transforming in cell culture assays. Many other examples of minor sequence variation have been reported but there is no evidence that they are of functional importance in EBV-associated disease. |
| Databáze: | OpenAIRE |
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