Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors
| Autor: | Thomas Lemster, Brigitte Baldeyrou, Amélie Lansiaux, Marie-Paule Hildebrand, Ulf Pindur, Christoph Keuser, Kerstin Benzschawel, Marie-Hélène David-Cordonnier |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
medicine.drug_class Topoisomerase Inhibitors DNA Footprinting Context (language use) Antineoplastic Agents Ligands chemistry.chemical_compound Structure-Activity Relationship Cell Line Tumor Drug Discovery medicine Structure–activity relationship Humans Pyrroles Pharmacology biology Molecular Structure Chemistry Topoisomerase Organic Chemistry Distamycins Netropsin General Medicine DNA DNA Minor Groove Binding Intercalating Agents Acridone Drug Design Acridine biology.protein Topoisomerase inhibitor |
| Zdroj: | European journal of medicinal chemistry. 42(6) |
| ISSN: | 0223-5234 |
| Popis: | In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-terminal end. As intercalating tricyclic systems acridone, acridine, anthraquinones and in a special case iminostilbene terminate the N-terminal end of the pyrrole chain. The cytotoxicity was examined by the NCI antitumor screening, furthermore, biophysical as well as biochemical studies were performed in order to get some information about the DNA binding properties and topoisomerase inhibition effect of this new series of molecules. |
| Databáze: | OpenAIRE |
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