Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri

Autor:	Yohei Doi, Jason W. Bennett, Patrick Mc Gann, Brendan W. Corey, Robert J. Cybulski, Alina Iovleva, Christi L. McElheny, Lan Preston, Katie R. Margulieux, Francois Lebreton
Rok vydání:	2021
Předmět:	Transposable element Carbapenem Heterologous Microbial Sensitivity Tests Ceftazidime beta-Lactamases Microbiology 03 medical and health sciences Tandem repeat Bacterial Proteins Mechanisms of Resistance Gene duplication medicine polycyclic compounds Pharmacology (medical) Gene 030304 developmental biology Pharmacology 0303 health sciences biology 030306 microbiology ceftazidime-avibactam CRE Citrobacter koseri biochemical phenomena metabolism and nutrition biology.organism_classification Ceftazidime/avibactam bacterial infections and mycoses Anti-Bacterial Agents Drug Combinations Klebsiella pneumoniae KPC Infectious Diseases Carbapenems Azabicyclo Compounds medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy
ISSN:	1098-6596
Popis:	KPC-82 is a KPC-2 variant identified in a carbapenem-nonsusceptible Citrobacter koseri that confers high-level resistance to ceftazidime-avibactam. Genomic analysis revealed that bla KPC-82 is carried by a chromosomally integrated Tn 4401 transposon (disrupting porin gene phoE ) and evolved by a 6-nucleotide tandem repeat duplication causing a two-amino-acid insertion (Ser-Asp) within the Ala 267 -Ser 275 loop.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d500e6bd24721e310b9d952bf23a8f7f https://pubmed.ncbi.nlm.nih.gov/33972237 Zobrazit plný text záznamu