Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality

Autor: Maria Gabriella Colucci, Isabella D'Antuono, Fabio Apone, Antonio F. Logrieco, Vito Linsalata, Luigi Michele Sena, Antonietta Carola, Angela Cardinali
Rok vydání: 2018
Předmět:
0301 basic medicine
Antioxidant
medicine.medical_treatment
Phytochemicals
Inulin
Pharmaceutical Science
Nitric Oxide
Article
Analytical Chemistry
Microcirculation
Artichoke Extract
lcsh:QD241-441
Young Adult
03 medical and health sciences
chemistry.chemical_compound
lcsh:Organic chemistry
Cynara scolymus
Drug Discovery
Gene expression
Human Umbilical Vein Endothelial Cells
medicine
Humans
Food science
Physical and Theoretical Chemistry
by-products
Chromatography
High Pressure Liquid
polyphenols
cosmetic ingredients
2. Zero hunger
cosmetic ingredient
030109 nutrition & dietetics
Tight junction
Plant Extracts
Chemistry
Macrophages
Organic Chemistry
Endothelial Cells
Skin Aging
Endothelial stem cell
030104 developmental biology
vascular aging
Chemistry (miscellaneous)
Polyphenol
Molecular Medicine
Female
Biomarkers
artichoke
Zdroj: Molecules
Volume 23
Issue 11
Molecules (Basel, Online) 23 (2018): 2729. doi:10.3390/molecules23112729
info:cnr-pdr/source/autori:D'Antuono, I.; Carola, A.; Sena, L.M.; Linsalata, V.; Cardinali, A.; Logrieco, A.F.; Colucci, M.G.; Apone, F./titolo:Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality/doi:10.3390%2Fmolecules23112729/rivista:Molecules (Basel, Online)/anno:2018/pagina_da:2729/pagina_a:/intervallo_pagine:2729/volume:23
Molecules, Vol 23, Iss 11, p 2729 (2018)
ISSN: 1420-3049
DOI: 10.3390/molecules23112729
Popis: Artichoke is a characteristic crop of the Mediterranean area, recognized for its nutritional value and therapeutic properties due to the presence of bioactive components such as polyphenols, inulin, vitamins and minerals. Artichoke is mainly consumed after home and/or industrial processing, and the undersized heads, not suitable for the market, can be used for the recovery of bioactive compounds, such as polyphenols, for cosmetic applications. In this paper, the potential skin anti-age effect of a polyphenolic artichoke extract on endothelial cells was investigated. The methodology used was addressed to evaluate the antioxidant and anti-inflammatory activities and the improvement of gene expression of some youth markers. The results showed that the artichoke extract was constituted by 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids. The extract induced important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, acted as a potential anti-inflammatory agent, protected the lymphatic vessels from oxidative damage by ROS formation, and enhanced the cellular cohesion by reinforcing the tight junction complex. In addition, the artichoke extract, through the modulation of molecular pathways, improved the expression of genes involved in anti-ageing mechanisms. Finally, clinical testing on human subjects highlighted the enhancement by 19.74% of roughness and 11.45% of elasticity from using an artichoke extract cosmetic formulation compared to placebo cream.
Databáze: OpenAIRE
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