Impact of age-related comorbidity on results of colorectal cancer surgery
| Autor: | Franco Roviello, Giovanni De Marco, Enrico Pinto, Guido Cerullo, Daniele Marrelli, Corrado Pedrazzani, Alessandro Neri, Alfonso De Stefano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Brief Article post-operative complications Colorectal cancer Co-morbidity colorectal cancer Comorbidity Kaplan-Meier Estimate Group A Gastroenterology elderly Group B Young Adult Postoperative Complications Colorectal cancer surgery Internal medicine Age related 80 and over Medicine Humans aged Young adult Survival rate Aged 80 and over business.industry Age Factors General Medicine Middle Aged medicine.disease Surgery Survival Rate Treatment Outcome Female business Colorectal Neoplasms |
| Popis: | AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly better for group A (75.2% vs 55%, P = 0.006), whereas no significant difference was observed considering disease-specific survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a significant number of patients is alive 5 years after CRC resection. |
| Databáze: | OpenAIRE |
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