Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters
| Autor: | Claudia Pollera, Daniela Braida, Gianpietro Bondiolotti, Giorgio Poli, Silvio R. Bareggi, M. Puricelli, E.A.M. Formentin, Mariaelvina Sala, Wilma Ponti |
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| Rok vydání: | 2009 |
| Předmět: |
Biogenic Amines
Time Factors Scrapie Motor Activity Pharmacology medicine.disease_cause Antioxidants Synapse Pathogenesis Lipid peroxidation Random Allocation chemistry.chemical_compound Neurochemical Memory Cricetinae Avoidance Learning medicine Animals Molecular Biology Chelating Agents Analysis of Variance Memory Disorders Mesocricetus biology General Neuroscience Clioquinol Brain biology.organism_classification Immunohistochemistry chemistry Immunology Female Lipid Peroxidation Neurology (clinical) Oxidative stress Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1280:195-200 |
| ISSN: | 0006-8993 |
| Popis: | Prion protein (PrP) is a glycoprotein expressed on the surface of neurons and glial cells. Its pathological isoform (PrP(res)) is protease resistant, and involved in the pathogenesis of a number of transmissible encephalopathies (TSEs). One common feature of neurodegenerative diseases, including TSEs, is oxidative stress, which may be responsible not only for the dysfunction or death of neuronal cells, but also cognitive deficits. Clioquinol (5-chloro-7-iodo-8-quinolinol) chelates zinc and copper, which are involved in the deposition of amyloid plaques and acts as an antioxidant; increased lipid peroxidation has also been demonstrated in the early phases of PrP propagation. The aim of this study was to investigate the effects of clioquinol on the changes in motor and cognitive behaviours induced by scrapie infection, as well as its effects on oxidative stress and the neurotransmitters known to be involved in motor and cognitive functions. The results show that clioquinol counteracts the massive memory deficit induced by scrapie infection. This effect is not paralleled by neurochemical changes because the levels of all of the biogenic amines and their metabolites were reduced despite clioquinol treatment. The main biochemical change induced by clioquinol was a marked reduction in lipid peroxidation at all time points. The antioxidant effect of clioquinol can reduce functional impairment and thus improve memory, but clioquinol does not reduce PrP deposition or synapse loss, as indicated by the unchanged Western blot, histopathological and histochemical findings. |
| Databáze: | OpenAIRE |
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