Uridine treatment prevents REM sleep deprivation-induced learning and memory impairment
| Autor: | Guldal Gulec Suyen, Busra Ocalan, Nevzat Kahveci, Aysen Cakir, Cansu Koc |
|---|---|
| Přispěvatelé: | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı., Öcalan, Büşra, Çakır, Ayşen, Koç, Cansu, Kahveci, Nevzat, AAA-4754-2022, A-6819-2018, N-9927-2019, AAL-1786-2020, AAG-7070-2021 |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Rats wistar Supplementation Molecular biology Maze learning Cyclic AMP responsive element binding protein Hippocampus Morris water navigation task Wistar rat chemistry.chemical_compound 0302 clinical medicine Behavior change Tubulin Calcium calmodulin dependent protein kinase II Cyclic AMP Medicine BRAIN Priority journal General Neuroscience Phosphotransferase Long-term potentiation General Medicine Morris water maze test Maze test Docosahexaenoic acid Sleep deprivation Flower Memory disorder Drug therapy medicine.symptom Ltp Beta tubulin Morris water maze Treatment indication Memory short-term Memory Consolidation REM Sleep Slow Wave Sleep medicine.medical_specialty Sodium chloride Western blot Neurosciences & neurology Stress Article 03 medical and health sciences Internal medicine Memory impairment Animals Cyclic adenosine monophosphate Animal model Uridine Creb phosphorylation Behavior Cdp-choline business.industry Animal Neurosciences Long term potentiation Nonhuman Increases Rats Drug effect 030104 developmental biology Endocrinology Metabolism chemistry Short term memory Rat Calmodulin kinase-II Rem sleep deprivation Animal experiment business Calcium-Calmodulin-Dependent Protein Kinase Type 2 Nucleoside Controlled study 030217 neurology & neurosurgery |
| Popis: | Previous studies have shown that sleep plays an important role in cognitive functions and sleep deprivation impairs learning and memory. Uridine is the main pyrimidine nucleoside found in human blood circulation and has beneficial effects on cognitive functions. The aim of the present study was to investigate the effects of uridine administration on learning and memory impairment in sleep-deprived rats. Flower pot method was used to induce REM sleep deprivation. Uridine-treated groups received 1 mmol/kg uridine and control groups received 1 ml/kg saline (0.9% NaCl) twice a day for four days and once a day on the 5th day intraperitoneally. Learning and memory performances were measured using Morris water maze (MWM) test. We also measured the ratios of total calcium-calmodulin dependent kinase II (tCaMKII)/β-tubulin and phosphorylated cyclic adenosine monophosphate (cAMP) response element binding protein (pCREB)/β-tubulin, long-term potentiation (LTP) related molecules, using western blot analysis on the hippocampus. The results showed that REM sleep deprivation impaired learning and memory and also decreased the ratios of tCaMKII and pCREB. Uridine treatment enhanced learning and memory parameters in REM sleep-deprived rats. Additionally, decreases in tCaMKII and pCREB were prevented by uridine treatment. These data suggest that administration of uridine for five consecutive days prevents REM sleep deprivation-induced deficits in learning and memory associated with enhanced tCaMKII and pCREB ratios in the hippocampus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|