Influence of age and sexual status on the development of toxic effects in the male rat fed aflatoxins
| Autor: | William T. Shalkop, Emory C. Leffel, Herbert F. Righter, H. Dwight Mercer |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Aflatoxin medicine.medical_specialty Time Factors Biology Toxicology chemistry.chemical_compound Sex Factors Animal science Aflatoxins Stress Physiological Internal medicine medicine Animals Testosterone Castration Pharmacology Rapid weight loss Body Weight Age Factors Rats Inbred Strains Feeding Behavior Diet Rats Endocrinology chemistry |
| Zdroj: | Toxicology and Applied Pharmacology. 21:435-439 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(72)90001-4 |
| Popis: | Male Fischer rats, 12 wk old, were fed 12 mg/kg aflatoxins in the diet. Severe reduction in feed intake and rapid weight loss were observed; mortality was 75–100% within 2 wk. Prepubertal males fed the same diet for 5 wk maintained pretreatment feed intake levels and gained considerable weight; survival was 100%. When the aflatoxin diet was fed to 7- and 9-wk-old males, mortality decreased. Castration afforded a 100% sparing effect from mortalities when performed before 10 wk of age, but had no beneficial action after this time. Testosterone administration resulted in 100% mortality in aflatoxin-fed castrates whereas no fatalities occurred in castrates fed aflatoxin only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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