Total synthesis of pyoverdin D
| Autor: | Roi Mashiach, Michael M. Meijler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Siderophore
Stereochemistry Iron Siderophores Pyoverdin D 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry chemistry.chemical_compound medicine Humans Physical and Theoretical Chemistry chemistry.chemical_classification Catechol Molecular Structure 010405 organic chemistry Pseudomonas aeruginosa Organic Chemistry Total synthesis Chromophore 3. Good health 0104 chemical sciences Amino acid chemistry Oligopeptides |
| Zdroj: | Organic Letters |
| ISSN: | 1523-7060 |
| DOI: | 10.1021/ol400490s |
| Popis: | Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including (δ)N-formyl-(δ)N-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total synthesis of pyoverdin D. |
| Databáze: | OpenAIRE |
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