Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy

Autor: Laurence Motte, Anouchka Plan Sangnier, Magali Fradet, Aurore Van de Walle, Claire Wilhelm, Romain Aufaure, Yoann Lalatonne, Erwann Guénin
Přispěvatelé: Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Rok vydání: 2020
Předmět:
Materials science
Photothermal Therapy
[SDV]Life Sciences [q-bio]
education
Biomedical Engineering
Metal Nanoparticles
Nanoparticle
Nanotechnology
Endosomes
02 engineering and technology
010402 general chemistry
01 natural sciences
General Biochemistry
Genetics and Molecular Biology
law.invention
Biomaterials
law
Neoplasms
[CHIM]Chemical Sciences
Humans
Absorption (electromagnetic radiation)
neoplasms
health care economics and organizations
Nanotubes
fungi
technology
industry
and agriculture
food and beverages
Photothermal therapy
equipment and supplies
021001 nanoscience & nanotechnology
Laser
3. Good health
0104 chemical sciences
surgical procedures
operative
Colloidal gold
gold nanoparticles
Heat generation
PC-3 Cells
cancer cells
Nanorod
cell uptake
Gold
0210 nano-technology
Dispersion (chemistry)
Nanospheres
Zdroj: Advanced Biosystems
Advanced Biosystems, Wiley-VCH, 2020, 4 (4), pp.1900284. ⟨10.1002/adbi.201900284⟩
ISSN: 2366-7478
DOI: 10.1002/adbi.201900284
Popis: Gold nanoparticles can act as photothermal agents to generate local tumor heating and subsequent depletion upon laser exposure. Herein, photothermal heating of four gold nanoparticles and the resulting induced cancer cell death are systematically assessed, within extra- or intracellular localizations. Two state-of-the-art gold nanorods are compared with small nanospheres (single-core) and nanoraspberries (multicore). Heat generation is measured in water dispersion and in cancer cells, using lasers at wavelengths of 680, 808, and 1064 nm, covering the entire range used in photothermal therapy, defined as near infrared first (NIR-I) and second (NIR-II) windows, with NIR-II offering more tissue penetration. When dispersed in water, gold nanospheres provide no significant heating, gold nanorods are efficient in NIR-I, and only gold nanoraspberries are still heating in NIR-II. However, in cells, due to endosomal confinement, all nanoparticles present an absorption red-shift translating visible and NIR-I absorbing nanoparticles into effective NIR-I and NIR-II nanoheaters, respectively. The gold nanorods then become competitive with the multicore nanoparticles (nanoraspberries) in NIR-II. Similarly, once in cells, gold nanospheres can be envisaged for NIR-I heating. Remarkably, nanoraspberries are efficient nanoheaters, whatever the laser applied, and the extra- versus intra-cellular localization demonstrates treatment versatility.
Databáze: OpenAIRE
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