Stereoselective Self-Assembly of DNA Binding Helicates Directed by the Viral β-Annulus Trimeric Peptide Motif
| Autor: | Miguel Vázquez López, M. Eugenio Vázquez, Jacobo Gómez-González, Giuseppe Sciortino, David Bouzada, Jean-Didier Maréchal, Lidia A. Pérez-Márquez |
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| Přispěvatelé: | Xunta de Galicia, Ministerio de Economía y Empresa (España), Universidad de Santiago de Compostela, Generalitat de Catalunya, Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Química Inorgánica, Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Pharmacology Binding Sites Supramolecular structures and assemblies Chemistry Communication Organic Chemistry Monomers Biomedical Engineering European Regional Development Fund Pharmaceutical Science Stereoisomerism Bioengineering DNA Peptides and proteins Ligands Plant Viruses Genetics Nucleic Acid Conformation media_common.cataloged_instance European union Peptides Humanities Biotechnology media_common |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Bioconjugate Chemistry |
| Popis: | Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions. Financial support from the Spanish grant RTI2018-099877-B-I00, the Xunta de Galicia (Centro singular de Investigación de Galicia accreditation 2016–2019, ED431G/09, and ED431B 2018/04), and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged. J.G.-G. thanks the Spanish MINECO for his FPI fellowship. D.B. thanks the CIQUS for his 2018 PhD fellowship. G.S. and J.-D.M. thank Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) for the financial support. Finally, we would like to thank Prof. Kazunori Matsuura at Tottori University for his valuable input during the preparation of this manuscript. |
| Databáze: | OpenAIRE |
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