Clinical practice of acute pancreatitis in Japan: An analysis of nationwide epidemiological survey in 2016

Autor: Atsushi Masamune, Kazuhiro Kikuta, Shin Hamada, Ichiro Tsuji, Yoshifumi Takeyama, Tooru Shimosegawa, Kazuichi Okazaki, Ryotaro Matsumoto, Kiyoshi Kume, Shin Miura, Tetsuya Takikawa, Seiji Hongo, Yu Tanaka, Toshitaka Sakai, Masayuki Ueno, Jun Unno, Masao Toki, Mamoru Nishimura, Katsuya Kitamura, Kasen Kobashigawa, Kiyoshi Ashida, Kuniyuki Takahashi, Takashi Watanabe, Yuichirou Sato, Akihiko Satoh, Naoki Yoshida, Kei Tanaka, Hiromu Kondo, Noriaki Suzuki, Hiroko Sato, Akira Mitoro, Kazuhiro Minami, Eisuke Iwasaki, Kosuke Okuwaki, Tsuyoshi Mukai, Yasushi Kudo, Shunjiro Azuma, Yasuhito Takeda, Morimichi Setsuda, Kohei Tsuchida, Atsushi Irisawa, Daisuke Motoya, Nakao Shirahata, Keisuke Iwata, Noriko Oza, Yasunori Kawaguchi, Atsumi Hoshino, Atsuyuki Hirano, Ichiro Sakakihara, Noriko Watanabe, Hiroyuki Funayama, Yuji Nakamura, Tatuo Yamamoto, H.Hiroshi Uchida, Yusuke Iizawa, Mahiro Imamura, Masanari Sekine, Kazuo Inui, Satoshi Yamamoto, Syuichi Sato, Shuji Ishii, Takayuki Yakushijin, Katsutoshi Yamamoto, Tomohiro Masaka, Motoyuki Yoshida, Toshihiko Arizumi, Manabu Goto, Mamoru Takenaka, Hiroyuki Miyakawa, Yuichiro Otsuka, Masaaki Nishi, Kanetoshi Suwa, Junichi Sakagami, Masahiro Satoh, Hideaki Koga, Tadayuki Takagi, Masatsugu Nagahama, Katsuko Hatayama, Naoya Kaneko, Masafumi Mori, Yousuke Nakai, Yuji Iwashita, Kunio Iwatsuka, Kazunao Hayashi, Shuji Terai, Hiroyuki Kaneto, Takao Nishikawa, Midori Uchi, Mitsuyoshi Honjo, Tomofumi Takagi, Kazuhiro Mizukami, Tetsuo Tamura, Toshifumi Gushima, Ai Sato, Kyoko Shimizu, Yukio Aruga, Kouji Nonogaki, Miyuki Kaino, Takuji Iwashita, Mio Tsuruoka, Masato Miura, Hirofumi Hasegawa, Tetsunari Takai, Hiroyuki Yokota, Toshio Fujisawa, Kota Uetsuki, Takashi Kobayashi, Naohisa yamaji, Takao Itoi, Takashi Muraki, Takayuki Watanabe, Osamu Inatomi, Tomoyuki Ushijima, Yusuke Takehara, Hiroshi Kawamura, Mitsuharu Fukasawa, Hideki Hagiwara, Hiroyuki Tamura, Takashi Moriya, Masaki Kuwatani, Yuki Kawaji, Terumi Kamisawa, Makoto Abue, Masanori Fukunishi, Hirohiko Onoyama, Satoshi Mochizuki, Kimi Sumimoto, Masanori Koyabu, Akiyoshi Nishio, Masayuki Sakao, Yoshiki Imamura, Hajime Ohta, Naruo Nishimura, Masahiro Shiihara, Hideaki Anan, Masayo Motoya, Mitsuru Chiba, Tomohiro Deguchi, Yasuhide Kofunato, Naoya Sawada, Kazuhiro Katada, Shimpei Matsumoto, Syunichi Higashide, Hiroyuki Okano, Masaharu Ishida, Masato Yamazaki, Naoshi Tamura, Takeshi Muraoka, Norimitsu Uza, Yuzo Kodama, Shinichiro Muro, Nao Fujimori, Takaaki Ikeda, Naoto Shimokawahara, Naoya Otsu, Yoichi Yano, Shuichiro Sugawara, Kenta Takaura, Yasuhiro Ogura, Takayuki Furuuchi, Masayuki Shibasaki, Masanobu Kishimoto
Rok vydání: 2020
Předmět:
Zdroj: Pancreatology. 20:629-636
ISSN: 1424-3903
DOI: 10.1016/j.pan.2020.04.013
Popis: Background To provide updates on clinical practice of acute pancreatitis (AP) in Japan, we conducted a nationwide epidemiological survey. Methods This study consisted of a two-staged survey; the number of AP patients was estimated by the first-stage survey and their clinical features were examined by the second-stage survey. We surveyed AP patients who had visited hospitals in 2016. Results The estimated number of AP patients in 2016 was 78,450, with an overall incidence of 61.8 per 100,000 persons. We obtained detailed clinical information of 2994 AP patients, including 706 (23.6%) severe cases classified according to the Japanese severity criteria. The male-to-female sex ratio was 2.0, and the mean age at onset was 59.9 years in males and 66.5 years in females. Alcohol was the most common etiology (42.8%) in males and gallstones in females (37.7%). The AP-associated mortality was 6.1% in severe AP cases, which was decreased by 40% compared to the 2011 survey. Antibiotics were administered to most cases, with carbapenem being frequently used. Enteral nutrition was given in 31.8% of severe cases, but majority cases received after 48 h. Among the 107 patients who received intervention for walled-off necrosis, five patients received surgery-first approach, 66 received endoscopic ultrasound-guided transluminal drainage, and 19 underwent step-up approach. Conclusions We clarified the current status of AP in Japan including the significant reduction of mortality in severe cases, shift to endoscopic approaches for walled-off necrosis, and poor compliance of the recommendations in the guidelines including management of enteral nutrition and antibiotic administration.
Databáze: OpenAIRE
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