Effect of cisapride on gastroesophageal reflux in children with chronic bronchopulmonary disease: a double-blind cross-over pH-monitoring study
| Autor: | Zimbu N. Saye, Fernand Geubelle, Pierre Ph. Forget |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Time Factors Placebo Ph monitoring Gastroenterology Double blind Esophagus Double-Blind Method Piperidines Internal medicine medicine Humans Lung Diseases Obstructive Adverse effect Sleep period Child Cross over Cisapride business.industry Reflux Infant Hydrogen-Ion Concentration Anesthesia Child Preschool Pediatrics Perinatology and Child Health Gastroesophageal Reflux Female business medicine.drug |
| Zdroj: | Pediatric pulmonology. 3(1) |
| ISSN: | 8755-6863 |
| Popis: | Fourteen patients with chronic bronchopulmonary disease and suspected of having gastroesophageal reflux were studied for 16 hr by intraesophageal pH monitoring to investigate the effect of the prokinetic drug cisapride. Cisapride was administered orally in a double-blind cross-over study. The initial dose was 0.3 mg/kg, followed by 0.15 mg/kg every 4 hr for 12 hr. Cisapride was shown to be superior to placebo in reducing gastroesophageal reflux. Both during the total recording period and during the sleep period, cisapride significantly decreased the percentage of time during which the pH was 4 or less (vs placebo; total period, −60%; sleep, −80%) and reduced the number of reflux spells of at least 5 min (−64%; −92%). No adverse effects of cisapride were observed. Pediatr Pulmonol 1987; 3:8–12. |
| Databáze: | OpenAIRE |
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