Multiple Forms of Multifunctional Proteins in Health and Disease
| Autor: | Erika Cruz-Bonilla, Adriana Espinosa-Cantú, Alexander DeLuna, Lianet Noda-Garcia |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein moonlighting Multiple forms Computer science Mini Review Context (language use) Computational biology Disease 03 medical and health sciences Cell and Developmental Biology 0302 clinical medicine pleiotropy Human multitasking moonlighting proteins lcsh:QH301-705.5 protein promiscuity Repertoire Cell Biology mechanisms of disease 030104 developmental biology Pleiotropy (drugs) Promiscuity lcsh:Biology (General) 030220 oncology & carcinogenesis multidomain proteins gene ontology Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 8 (2020) Frontiers in Cell and Developmental Biology |
| Popis: | Protein science has moved from a focus on individual molecules to an integrated perspective in which proteins emerge as dynamic players with multiple functions, rather than monofunctional specialists. Annotation of the full functional repertoire of proteins has impacted the fields of biochemistry and genetics, and will continue to influence basic and applied science questions - from the genotype-to-phenotype problem, to our understanding of human pathologies and drug design. In this review, we address the phenomena of pleiotropy, multidomain proteins, promiscuity, and protein moonlighting, providing examples of multitasking biomolecules that underlie specific mechanisms of human disease. In doing so, we place in context different types of multifunctional proteins, highlighting useful attributes for their systematic definition and classification in future research directions. |
| Databáze: | OpenAIRE |
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